Neural Interface Research
Laboratory





Publications

2022

  • W. S. Yu, L. Aquili, K. H. Wong, A. C. Y. Lo, L. L. H. Chan, Y.-S. Chan, L. W. Lim, "Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models," Annals of the New York Academy of Sciences, In Press (2022).

  • W. S. Yu, A. C.-K. Tse, L. Guan, J. L. Y. Chiu, S. Z. K. Tan, S. S. Khairuddin, S. Agadagba, A. C. Y. Lo, Y.-S. Chan, L. L. H. Chan, L. W. Lim, "Antidepressant-like effects of transcorneal electrical stimulation in rat models," Brain Stimulation, 15(3):843-856 (2022).

  • S. Agadagba, A. B. M. Eldaly, L. L. H. Chan, "Transcorneal Electrical Stimulation Induces Long-lasting Enhancement of Brain Functional and Directional Connectivity in Retinal Degeneration Mice," Frontiers in Cellular Neuroscience, 16:785199, eCollection (2022).

  • 2021

  • W.-S. Yu, S.-H. Kwon, S. K. Agadagba, L.-L.-H. Chan, K.-H. Wong, L.-W. Lim, "Neuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression," Cells, 10(9), 2492 (2021).

  • A. Malik, A. B. M. Eldaly, K. Chen, L. L. H. Chan, "Neuronal oscillatory signatures in the developing mouse visual cortex after short-term monocular deprivation," Cerebral Cortex, bhab372 (2021).

  • M. H. Chowdhury, A. B. M. Eldaly, S. K. Agadagba, R. C. C. Cheung, L. L. H. Chan, "Machine learning based hardware architecture for DOA measurement from mice EEG," IEEE Transactions on Biomedical Engineering, 69(1):314-324 (2021).

  • H. Xie, Y. Wang, Z. Ye, S. Fang, Z. Xu, T. Wu, L. L. H. Chan, "Monitoring Cortical Response and Electrode-Retina Impedance under Epiretinal Stimulation in Rats," IEEE Transactions on Neural Systems and Rehabilitation Engineering, 29: 1178-87 (2021).

  • 2020

  • S. Agadagba, X. Li, L. L. H. Chan, "Excitation of the Pre-frontal and Primary Visual Cortex in Response to Transcorneal Electrical Stimulation in Retinal Degeneration Mice," Frontiers in Neuroscience, 14:572299 (2020).

  • K. Chen, B. Hou, Y. Zhao, P. Yuan, D. Yao, L. L. H. Chan, "Residual contrast response in primary visual cortex of rats with inherited retinal degeneration," Vision Research, 177: 6-11 (2020).

  • B. Hou, K. Chen, Y. Zhao, L. L. H. Chan, "Variation in Spontaneous Activity and Visual Evoked Response in Primary Visual Cortex of the S334ter-3 Rats," International Conference on Energy, Environment and Bioengineerin (ICEEB), 185: 03034 (2020).

  • H. Gai, Y. Wang, L. L. H. Chan, B. C. Y. Chiu, "Identification of retinal ganglion cells from beta-III stained fluorescent microscopic images," Journal of Digital Imaging, 33: 1352-63 (2020).

  • D. Y. Tam, J. W.-T. Ho, M. S. Chan, C. H. Lau, T. J. H. Chang, H. M. Leung, L. S. Liu, F. Wang, L. L. H. Chan, C. Tin, P. K. Lo, "Penetrating the BloodBrain Barrier by Self-Assembled 3D DNA Nanocages as Drug Delivery Vehicles for Brain Cancer Therapy," ACS Applied Materials & Interfaces, 12, 26:28928-40 (2020).

  • K. Chen, Y. Zhao, T. Liu, Z. Su, H. Yu, L. L. H. Chan, T. Liu, D. Yao, "Monocular visual deprivation and ocular dominance plasticity measurement in the mouse primary visual cortex," Journal of Visualized Experiments, 156, e60600 (2020).
  • 2019

  • H. Cui, X. Xie, S. Xu, L. L. H. Chan, Y. Hu, "Electrochemical characteristics of microelectrode designed for electrical stimulation," BioMedical Engineering Online, 18:86 (2019).

  • C. Yu, L. Luo, L. L.-H. Chan, T. Rakthanmanon, S. Nutanong, "A fast LSH-based similarity search method for multivariate time series," Information Sciences, 476: 337-56 (2019).

  • J. P.-W. Chow, H. S.-H. Chung, L. L.-H. Chan, R. Shen, S. C. Tang, "Optimal design and experimental assessment of a wireless power transfer system for home-cage monitoring," IEEE Transactions of Power Electronics, 34(10): 9779-93 (2019).

  • H. Kuang, L. Chen, L. L. H. Chan, R. C. C. Cheung, H. Yan, "Feature selection based on tensor decomposition and object proposal for nighttime multi-class vehicle detection," IEEE Transactions on Systems, Man, and Cybernetics: Systems, 49, 1: 71-80 (2019).
  • 2018

  • Y. Duan, H. Kuang, W. Qiu, L.L.H. Chan, H. Yan, "Cascade feature selection and coarse-to-fine mechanism for nighttime multiclass vehicle detection," Journal of Electronic Imaging, 27(3), 033042 (2018).

  • Y. Wang, K. Chen, L. L. H. Chan, "Responsive neural activities in the primary visual cortex of retinal degenerated rats," Neuroscience, 383: 84-97 (2018).

  • Q. Jiang, G. Li, H. Zhao, W. Sheng, L. Yue, M. Su, S. Weng, L. L.-H. Chan, Q. Zhou, M. S. Humayun, W. Qiu, H. Zheng, "Temporal-spatial neuromodulation of retinal ganglion cells by low-frequency focused ultrasound stimulation," IEEE Transactions on Neural Systems and Rehabilitation Engineering, 26(5):969-76 (2018).

  • H. Kuang, C. Liu, L. L. H. Chan, H. Yan, "Multi-class fruit detection based on image region selection and improved object proposals," Neurocomputing, 283:241-55 (2018).
  • 2017

  • J. Wang, H. Xie, T. Chung, L. L. H. Chan, S. W. Pang, ''Neural probes with integrated temperature sensors for monitoring retina and brain implantation and stimulation," IEEE Transactions on Neural Systems and Rehabilitation Engineering, 25(9):1663-73 (2017).

  • G. Kumar, N. P. B. Au, E. N. Y. Lei, Y. L. Mak, L. L. H. Chan, M. H. W. Lam, L. L. Chan, P. K. S. Lam, C. H. E. Ma, "Acute exposure to pacific ciguatoxin reduces electrocephalogram activity and disrupts neurotransmitter metabolic pathways in motor cortex," Molecular Neurobiology, 54(7):5590-603 (2017).

  • M. Gao, Y. Yu, H. Zhao, G. Li, H. Jiang, C. Wang, F. Cai, L. L.-H. Chan, B. Chiu, W. Qian, W. Qiu, H. Zheng, "Simulation study of an ultrasonic retinal prosthesis with a novel contact-lens array for non-invasive retinal stimulation," IEEE Transactions on Neural Systems and Rehabilitation Engineering, 54(7):5590-603 (2017).

  • L. U. Vinzons, L. Shu, S.P. Yip, C.-Y. Wong, L. L. H. Chan, J. C. Ho, "Unraveling the morphological evolution and etching kinetics of porous silicon nanowires during metal-assisted chemical etching," Nanoscale Research Letters, 12, 385 (2017).

  • H. Kuang, K.-F. Yang, L. Chen, Y.-J. Li, L. L. H. Chan, H. Yan, "Bayes saliency based object proposal generator nighttime traffic images," IEEE Transactions on Intelligent Transportation Systems, 19(3), 814-25 (2017).

  • X.-T. Huang, Y. Zhu, L. L. H. Chan, Z. Zhao, H. Yan, "Inference of cellular level signaling networks using single-cell gene expression data in C. elegans reveals mechanisms of cell fate specification," Bioinformatics, 33(10):1528-35 (2017).

  • H. Kuang, X. Zhang, Y.-J. Li, L. L. H. Chan, H. Yan, "Nighttime vehicle detection based on bio-inspired image enhancement and weighted score-level feature fusion," IEEE Transactions on Intelligent Transportation Systems, 18(4):927-36 (2017).
  • 2016

  • Y. Wang, K. Chen, P. Xu, T. K. Ng, L. L. H. Chan, "Spontaneous neural activity in the primary visual cortex of retinal degenerated rats," Neuroscience Letters, 623:42-6 (2016).

  • K. Chen, Y. Wang, X. Liang, Y. Zhang, T. K. Ng, L. L. H. Chan, "Electrophysiology alterations in primary visual cortex neurons of retinal degeneration (S334ter-line-3) rats," Scientific Reports, 6:26793 (2016).

  • H. Kuang, L. Chen, F. Gu, J. Chen, L. L. H. Chan, H. Yan, "Combining region of interest extraction and image enhancement for nighttime vehicle detection," IEEE Intelligent Systems, 31(3):57-65 (2016).

  • H. Kuang, L. L. H. Chan, C. Liu, H. Yan, "Fruit classification based on weighted score-level feature fusion," Journal of Electronic Imaging, 25(1):013009 (2016).

  • X.-T. Huang, Y. Zhu, L. L. H. Chan, Z. Zhao, H. Yan, "An integrative C. elegans protein-protein interaction network with reliability assessment based on probabilistic graphical model," Molecular BioSystems, 12(1):85-92 (2016).
  • 2015

  • J. P. W. Chow, N. Chen, H. S. H. Chung, L. L. H. Chan, "An investigation into the use of orthogonal winding in loosely-coupled link for improving transfer efficiency under coil misalignment," IEEE Transactions on Power Electronics, 30(10):5632-49 (2015).

  • A. Khalifa, Z. Gao, A. Bermak, Y. Wang, L. L. H. Chan, "A novel method for the fabrication of a high-density carbon nanotube microelectrode array," Sensing and Bio-Sensing Research, 5:1-7 (2015).

  • V. W. Ho, M.-K. Wong, X. An, D. Guan, J. Shao, H. C. K. Ng, X. Ren, K. He, J. Liao, Y. Ang, L. Chen, X. Huang, B. Yan, Y. Xia, L. L. H. Chan, K. L. Chow, H. Yan, Z. Zhao, "Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry," Molecular Systems Biology, 11(6):814 (2015).

  • X. Sui, Y. Huang, F. Feng, C. Huang, L. L. H. Chan, G. Wang, "3D finite element modeling of epi-retinal stimulation: impact of prosthetic electrode size and distance from the retina," International Journal of Artificial Organs, 38(5):277-287 (2015).
  • 2014 and Before

  • C.-E. Stephany, L. L. H. Chan, S. N. Parivash, H. M. Dorton, M. Piechowicz, S. Qiu, A. W. McGee, "Plasticity of binocularity and visual acuity are differentially limited by nogo receptor," Journal of Neuroscience, 34(35):11631-40 (2014).

  • X. Huang, L. Chen, H. Chim, L. L. H. Chan, Z. Zhao, H. Yan, "Boolean genetic network model for the control of C. elegans early embryonic cell cycles," Biomedical Engineering Online, 12(1):S1-13 (2013).

  • L. Chen, L. L. H. Chan, Z. Zhao, H. Yan, "A novel cell nuclei segmentation method for 3D C. elegans embryonic time-lapse images," BMC Bioinformatics, 14(1):328 (2013).

  • A. Ray, L. L. H. Chan, A. Gonzalez, M. S. Humayun, J. D. Weiland, "Impedance as a method to sense proximity at the electrode-retina interface," IEEE Transactions on Neural Systems and Rehabilitation Engineering, 19(6):696-9 (2011).

  • L. L. H. Chan, E.-J. Lee, M. S. Humayun, J. D. Weiland, "Both electrical stimulation thresholds and SMI-32 immunoreactive retinal ganglion cell density correlate with age in S334ter line 3 rat retina," Journal of Neurophysiology, 105(6):2687-97 (2011).

  • A. Ray, G. Sun, L. Chan, N. M. Grzywacz, J. Weiland, and E.-J. Lee, "Morphological alterations in retinal neurons in the S334ter-line3 transgenic rat," Cell and Tissue Research, 339(3):481-91 (2010).
  • PhD Theses

  • Y. Wang, "Electrophysiological and Functional Alterations in the Primary Visual Cortex of Retina-Degenerated Rats," 2018.

  • H. Huang, "Night-time Vehicle Detection Based on Image Enhancement Object Proposal and Feature Fusion," 2017.

  • X. Huang, "Assessment, Inference, and Dynamic Analysis of Molecular Interaction Network in Caenorhabditis Elegans," 2016.