Neural Interface Research
Laboratory
HOME
RESEARCH
LAB MEMBERS
TEACHING
PUBLICATIONS
OPENING
NEWS
CONTACT
Publications
2023
S. K. Agadagba, L. W. Lim, L. L. H. Chan, "
Advances in Transcorneal Electrical Stimulation: From the Eye to the Brain
,"
Frontiers in Cellular Neuroscience
, Accepted (2023).
2022
A. Malik, A. B. M. Eldaly, S. K. Agadagba, Y. Zheng, X. Chen, J. He, L. L. H. Chan, "
Neuromodulation in the developing visual cortex after long-term monocular deprivation
,"
Cerebral Cortex
, bhac448 (2022).
W. S. Yu, L. Aquili, K. H. Wong, A. C. Y. Lo, L. L. H. Chan, Y.-S. Chan, L. W. Lim, "
Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models
,"
Annals of the New York Academy of Sciences
, 1515(1):249-265 (2022).
W. S. Yu, A. C.-K. Tse, L. Guan, J. L. Y. Chiu, S. Z. K. Tan, S. S. Khairuddin, S. Agadagba, A. C. Y. Lo, Y.-S. Chan, L. L. H. Chan, L. W. Lim, "
Antidepressant-like effects of transcorneal electrical stimulation in rat models
,"
Brain Stimulation
, 15(3):843-856 (2022).
S. Agadagba, A. B. M. Eldaly, L. L. H. Chan, "
Transcorneal Electrical Stimulation Induces Long-lasting Enhancement of Brain Functional and Directional Connectivity in Retinal Degeneration Mice
,"
Frontiers in Cellular Neuroscience
, 16:785199, (2022).
2021
W.-S. Yu, S.-H. Kwon, S. K. Agadagba, L.-L.-H. Chan, K.-H. Wong, L.-W. Lim, "
Neuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression
,"
Cells
, 10(9), 2492 (2021).
A. Malik, A. B. M. Eldaly, K. Chen, L. L. H. Chan, "
Neuronal oscillatory signatures in the developing mouse visual cortex after short-term monocular deprivation
,"
Cerebral Cortex
, 32(12):2657-2667 (2021).
M. H. Chowdhury, A. B. M. Eldaly, S. K. Agadagba, R. C. C. Cheung, L. L. H. Chan, "
Machine learning based hardware architecture for DOA measurement from mice EEG
,"
IEEE Transactions on Biomedical Engineering
, 69(1):314-324 (2021).
H. Xie, Y. Wang, Z. Ye, S. Fang, Z. Xu, T. Wu, L. L. H. Chan, "
Monitoring Cortical Response and Electrode-Retina Impedance under Epiretinal Stimulation in Rats
,"
IEEE Transactions on Neural Systems and Rehabilitation Engineering
, 29: 1178-87 (2021).
2020
S. Agadagba, X. Li, L. L. H. Chan, "
Excitation of the Pre-frontal and Primary Visual Cortex in Response to Transcorneal Electrical Stimulation in Retinal Degeneration Mice
,"
Frontiers in Neuroscience
, 14:572299 (2020).
K. Chen, B. Hou, Y. Zhao, P. Yuan, D. Yao, L. L. H. Chan, "
Residual contrast response in primary visual cortex of rats with inherited retinal degeneration
,"
Vision Research
, 177: 6-11 (2020).
B. Hou, K. Chen, Y. Zhao, L. L. H. Chan, "
Variation in Spontaneous Activity and Visual Evoked Response in Primary Visual Cortex of the S334ter-3 Rats
,"
International Conference on Energy, Environment and Bioengineerin (ICEEB)
, 185: 03034 (2020).
H. Gai, Y. Wang, L. L. H. Chan, B. C. Y. Chiu, "
Identification of retinal ganglion cells from beta-III stained fluorescent microscopic images
,"
Journal of Digital Imaging
, 33: 1352-63 (2020).
D. Y. Tam, J. W.-T. Ho, M. S. Chan, C. H. Lau, T. J. H. Chang, H. M. Leung, L. S. Liu, F. Wang, L. L. H. Chan, C. Tin, P. K. Lo, "
Penetrating the BloodBrain Barrier by Self-Assembled 3D DNA Nanocages as Drug Delivery Vehicles for Brain Cancer Therapy
,"
ACS Applied Materials & Interfaces
, 12, 26:28928-40 (2020).
K. Chen, Y. Zhao, T. Liu, Z. Su, H. Yu, L. L. H. Chan, T. Liu, D. Yao, "
Monocular visual deprivation and ocular dominance plasticity measurement in the mouse primary visual cortex
,"
Journal of Visualized Experiments
, 156, e60600 (2020).
2019
H. Cui, X. Xie, S. Xu, L. L. H. Chan, Y. Hu, "
Electrochemical characteristics of microelectrode designed for electrical stimulation
,"
BioMedical Engineering Online
, 18:86 (2019).
C. Yu, L. Luo, L. L.-H. Chan, T. Rakthanmanon, S. Nutanong, "
A fast LSH-based similarity search method for multivariate time series
,"
Information Sciences
, 476: 337-56 (2019).
J. P.-W. Chow, H. S.-H. Chung, L. L.-H. Chan, R. Shen, S. C. Tang, "
Optimal design and experimental assessment of a wireless power transfer system for home-cage monitoring
,"
IEEE Transactions of Power Electronics
, 34(10): 9779-93 (2019).
H. Kuang, L. Chen, L. L. H. Chan, R. C. C. Cheung, H. Yan, "
Feature selection based on tensor decomposition and object proposal for nighttime multi-class vehicle detection
,"
IEEE Transactions on Systems, Man, and Cybernetics: Systems
, 49, 1: 71-80 (2019).
2018
Y. Duan, H. Kuang, W. Qiu, L.L.H. Chan, H. Yan, "
Cascade feature selection and coarse-to-fine mechanism for nighttime multiclass vehicle detection
,"
Journal of Electronic Imaging
, 27(3), 033042 (2018).
Y. Wang, K. Chen, L. L. H. Chan, "
Responsive neural activities in the primary visual cortex of retinal degenerated rats
,"
Neuroscience
, 383: 84-97 (2018).
Q. Jiang, G. Li, H. Zhao, W. Sheng, L. Yue, M. Su, S. Weng, L. L.-H. Chan, Q. Zhou, M. S. Humayun, W. Qiu, H. Zheng, "
Temporal-spatial neuromodulation of retinal ganglion cells by low-frequency focused ultrasound stimulation
,"
IEEE Transactions on Neural Systems and Rehabilitation Engineering
, 26(5):969-76 (2018).
H. Kuang, C. Liu, L. L. H. Chan, H. Yan, "
Multi-class fruit detection based on image region selection and improved object proposals
,"
Neurocomputing
, 283:241-55 (2018).
2017
J. Wang, H. Xie, T. Chung, L. L. H. Chan, S. W. Pang, ''
Neural probes with integrated temperature sensors for monitoring retina and brain implantation and stimulation
,"
IEEE Transactions on Neural Systems and Rehabilitation Engineering
, 25(9):1663-73 (2017).
G. Kumar, N. P. B. Au, E. N. Y. Lei, Y. L. Mak, L. L. H. Chan, M. H. W. Lam, L. L. Chan, P. K. S. Lam, C. H. E. Ma, "
Acute exposure to pacific ciguatoxin reduces electrocephalogram activity and disrupts neurotransmitter metabolic pathways in motor cortex
,"
Molecular Neurobiology
, 54(7):5590-603 (2017).
M. Gao, Y. Yu, H. Zhao, G. Li, H. Jiang, C. Wang, F. Cai, L. L.-H. Chan, B. Chiu, W. Qian, W. Qiu, H. Zheng, "
Simulation study of an ultrasonic retinal prosthesis with a novel contact-lens array for non-invasive retinal stimulation
,"
IEEE Transactions on Neural Systems and Rehabilitation Engineering
, 54(7):5590-603 (2017).
L. U. Vinzons, L. Shu, S.P. Yip, C.-Y. Wong, L. L. H. Chan, J. C. Ho, "
Unraveling the morphological evolution and etching kinetics of porous silicon nanowires during metal-assisted chemical etching
,"
Nanoscale Research Letters
, 12, 385 (2017).
H. Kuang, K.-F. Yang, L. Chen, Y.-J. Li, L. L. H. Chan, H. Yan, "
Bayes saliency based object proposal generator nighttime traffic images
,"
IEEE Transactions on Intelligent Transportation Systems
, 19(3), 814-25 (2017).
X.-T. Huang, Y. Zhu, L. L. H. Chan, Z. Zhao, H. Yan, "
Inference of cellular level signaling networks using single-cell gene expression data in C. elegans reveals mechanisms of cell fate specification
,"
Bioinformatics
, 33(10):1528-35 (2017).
H. Kuang, X. Zhang, Y.-J. Li, L. L. H. Chan, H. Yan, "
Nighttime vehicle detection based on bio-inspired image enhancement and weighted score-level feature fusion
,"
IEEE Transactions on Intelligent Transportation Systems
, 18(4):927-36 (2017).
2016
Y. Wang, K. Chen, P. Xu, T. K. Ng, L. L. H. Chan, "
Spontaneous neural activity in the primary visual cortex of retinal degenerated rats
,"
Neuroscience Letters
, 623:42-6 (2016).
K. Chen, Y. Wang, X. Liang, Y. Zhang, T. K. Ng, L. L. H. Chan, "
Electrophysiology alterations in primary visual cortex neurons of retinal degeneration (S334ter-line-3) rats
,"
Scientific Reports
, 6:26793 (2016).
H. Kuang, L. Chen, F. Gu, J. Chen, L. L. H. Chan, H. Yan, "
Combining region of interest extraction and image enhancement for nighttime vehicle detection
,"
IEEE Intelligent Systems
, 31(3):57-65 (2016).
H. Kuang, L. L. H. Chan, C. Liu, H. Yan, "
Fruit classification based on weighted score-level feature fusion
,"
Journal of Electronic Imaging
, 25(1):013009 (2016).
X.-T. Huang, Y. Zhu, L. L. H. Chan, Z. Zhao, H. Yan, "
An integrative C. elegans protein-protein interaction network with reliability assessment based on probabilistic graphical model
,"
Molecular BioSystems
, 12(1):85-92 (2016).
2015
J. P. W. Chow, N. Chen, H. S. H. Chung, L. L. H. Chan, "
An investigation into the use of orthogonal winding in loosely-coupled link for improving transfer efficiency under coil misalignment
,"
IEEE Transactions on Power Electronics
, 30(10):5632-49 (2015).
A. Khalifa, Z. Gao, A. Bermak, Y. Wang, L. L. H. Chan, "
A novel method for the fabrication of a high-density carbon nanotube microelectrode array
,"
Sensing and Bio-Sensing Research
, 5:1-7 (2015).
V. W. Ho, M.-K. Wong, X. An, D. Guan, J. Shao, H. C. K. Ng, X. Ren, K. He, J. Liao, Y. Ang, L. Chen, X. Huang, B. Yan, Y. Xia, L. L. H. Chan, K. L. Chow, H. Yan, Z. Zhao, "
Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry
,"
Molecular Systems Biology
, 11(6):814 (2015).
X. Sui, Y. Huang, F. Feng, C. Huang, L. L. H. Chan, G. Wang, "
3D finite element modeling of epi-retinal stimulation: impact of prosthetic electrode size and distance from the retina
,"
International Journal of Artificial Organs
, 38(5):277-287 (2015).
2014 and Before
C.-E. Stephany, L. L. H. Chan, S. N. Parivash, H. M. Dorton, M. Piechowicz, S. Qiu, A. W. McGee, "
Plasticity of binocularity and visual acuity are differentially limited by nogo receptor
,"
Journal of Neuroscience
, 34(35):11631-40 (2014).
X. Huang, L. Chen, H. Chim, L. L. H. Chan, Z. Zhao, H. Yan, "
Boolean genetic network model for the control of C. elegans early embryonic cell cycles
,"
Biomedical Engineering Online
, 12(1):S1-13 (2013).
L. Chen, L. L. H. Chan, Z. Zhao, H. Yan, "
A novel cell nuclei segmentation method for 3D C. elegans embryonic time-lapse images
,"
BMC Bioinformatics
, 14(1):328 (2013).
A. Ray, L. L. H. Chan, A. Gonzalez, M. S. Humayun, J. D. Weiland, "
Impedance as a method to sense proximity at the electrode-retina interface
,"
IEEE Transactions on Neural Systems and Rehabilitation Engineering
, 19(6):696-9 (2011).
L. L. H. Chan, E.-J. Lee, M. S. Humayun, J. D. Weiland, "
Both electrical stimulation thresholds and SMI-32 immunoreactive retinal ganglion cell density correlate with age in S334ter line 3 rat retina
,"
Journal of Neurophysiology
, 105(6):2687-97 (2011).
A. Ray, G. Sun, L. Chan, N. M. Grzywacz, J. Weiland, and E.-J. Lee, "
Morphological alterations in retinal neurons in the S334ter-line3 transgenic rat
,"
Cell and Tissue Research
, 339(3):481-91 (2010).
PhD Theses
A. Malik, "Neural Dynamic Alteration and Therapeutic Intervention in the Visual Cortex Using a Mouse Model of Amblyopia," 2022.
S. K. Agadagba, "Neuromodulation of Electrocorticographic Response under Transcorneal Electrical Stimulation," 2022.
Y. Wang, "Electrophysiological and Functional Alterations in the Primary Visual Cortex of Retina-Degenerated Rats," 2018.
H. Huang, "Night-time Vehicle Detection Based on Image Enhancement Object Proposal and Feature Fusion," 2017.
X. Huang, "Assessment, Inference, and Dynamic Analysis of Molecular Interaction Network in Caenorhabditis Elegans," 2016.