High Density Neural Probe Arrays to Identify Neural Activities of Multiple Brain Nucleus

Neural probes were used in vivo at various sites to simultaneously study neural activities for correlations and basic understanding of the central nervous system. Potentially, these neural probe arrays could record, stimulate, and deliver chemicals for monitoring and treatment. The high precision, densely packed recording/stimulation sites on a single probe shank allows characterization of the synaptic integration in the complex of neuronal circuitry. We plan to use these integrated neural probes with wireless communication to deliver electrical or chemical signals into specific brain nucleus in various animal disease models to prevent or facilitate the recovery of the neuronal damage.

     

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(a) Local field potential of anterior cingulate cortex recorded in 16 channels of neural probes implanted in free moving rat. (b) Si-based neural probes with high-density electrode sites.