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Effect of Electrical Activity on Animal Model of Optic Nerve Regeneration

Members: Dr. Leanne Chan (EE) - Principle Investigator
Dr. Eddie Ma (BMS)
Prof. Stella W. Pang (EE)
Prof. Ying Li (BMS)

Axon fails to regenerate after central nervous system (CNS) injures. Overcoming the obstacle for functional recovery has become the major target of neuroscience. Blocking extracellular inhibitory alone has been reported to be insufficient to allow injured axons to regenerate. The retinal prosthesis and cochlear implant have proved the concept of restoring lost neuronal functions by artificial means. We have investigated the effect of electrical stimulation together with heat shock protein protection to promote axon regeneration after optic nerve injury.


Optic Nerve project

Time dependent study on retinal ganglion cell survival after ONC. A-H, Preservation of RGCs 1 week, 2 weeks, and 3 weeks after ONC in wt and hHsp27 mice. I, Quantification of RGC survival. J,K, Longitudinal sections through the optic nerve showing CTB labeled axons. Asterisk denotes the site for optic nerve injury.



Publication and Conference Presentations

  1. L. Chen, L. L. H. Chan, Z. Zhao, and H. Yan, “A novel cell nuclei segmentation method based on bi-directional prediction”, BMC Bioinformatics 14, 328 (2013).
  2. J. P. Chow, N. Chen, H. S. Chung, and L. L. H. Chan, “Misalignment Tolerable Coil Structure for Biomedical Applications with Wireless Power Transfer”, Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 775-778, 2013.
  3. L. L. H. Chan, Y. Wang, N. P. Au, and C. H. Ma, “The Role of Heat Shock Protein and Electrical Activity in promoting Nerve Regeneration in Mouse Retina”, Society for Neuroscience, 796.03/B20, San Diego, CA, 2013.
  4. C.-E. Stephany, L. L. H. Chan, H. M. Dorton, S. N. Parivash, and A.W. McGee, “Nogo Receptor 1 Regulate Plasticity of Distinct Circuits for Binocularity and Acuity”, Society for Neuroscience, 823.02/Z1, San Diego, CA, 2013.
  5. K. S. Chapman, L. L. H. Chan, C.-E. Stephany, and A. W. McGee, “Reactivating Ocular Dominance Plasticity in Adult Mice by Deletion of NgR1”, Society for Neuroscience, 823.03/Z2, San Diego, CA, 2013.